This course will provide students the opportunity to explore a variety of topics associated with the field of drug development.

Introduces the student to the principles of thermodynamics, ionic equilibrium, chemical kinetics and diffusion. Application of these principles to formulation, stability and dissolution of a drug product, and release from the dosage form for optimum therapeutic outcome. Required of entering graduate students in Pharmaceutics who do not have a Pharmacy background as well as those who do not pass the qualifying examination within the first year of the program.

Covers the basic principles of the surface and colloid chemistry and rheology, as these relate to the performance of dispersed system dosage forms including colloids, suspensions, emulsions, suppositories, aerosols, ointments, and transdermals. Required of entering graduate students in Pharmaceutics who do not have a Pharmacy background, and those who do not pass the qualifying examination within the first year of the program.

Basic principles of biopharmaceutics, bioavailability, and pharmacokinetics, including their application to the rational design of both dosage forms and maximally effective dosing regimens. Intended for graduate students who may not have sufficient previous exposure to biopharmaceutics and pharmakokinetics.

Designed to familiarize students with current pharmaceutics literature and to educate students in critical peer review in the pharmaceutics literature.

The processes of new drug development; target identification, drug discovery process, drug candidate evaluation, preclinical toxicity assessment, drug formulation and delivery, clinical trials for safety and efficacy, and FDA regulation on new drug application.

The allied fields of pharmacogenomics and personalized medicine have become areas of intense interest. Each patient responds to drugs and medical treatments in an individualized way, often having to do with underlying genetics. Individual genetic variance often impacts treatment efficacy, pharmaceutical responses, and toxicological adverse events. This course will consider these knowledge areas, which are at the cutting edge of medical advance. Aspects of personalized medicine that go beyond genetics, including the use of patient-matched stem cells will also be discussed.

Reports and discussions.

Individualized course for students desiring research experience in any of the areas of pharmacy other than the area chosen by the student for thesis research.

Includes topics not presently covered in courses which are pertinent to current departmental research and areas of recent development in the literature.

A cooperative presentation of the fundamentals of medicinal chemistry.

Introduction to the emerging field of chemical biology with a particular focus on the role it plays in understanding cellular signaling, drug design, and drug development.

Small organic molecules continue to be the preeminent form of therapeutic agents. The small molecules that constitute clinically used agents are developed through a highly interdisciplinary process involving chemists, biologists and healthcare workers in a process commonly referred to as drug discovery. The purpose of this course is to provide the student with a broad view of drug properties, drug function and the drug discovery process.

Reports and discussions.

Individualized course for students desiring research experience in any of the areas of medicinal chemistry other than the area chosen by the student for thesis research.

Current developments in Medicinal Chemistry. A course for students needing exposure to topics not covered in other department offerings.

Designed to familiarize students with current pharmaceutical sciences literature and to educate students in critical peer review of this literature.

Introduction to toxicologic risk assessment. Fundamentals of dose-response relationships and risk characterization, and their application in the establishment of permissible exposure limits for drugs and other chemicals in the environment or workplace.

Molecular mechanisms of drug action including occupation and rate theories. Characterization of receptors in-situ and in-vitro.

Drug absorption, distribution, excretion, metabolism, interaction, allergy, resistance, tolerance, idiosyncrasy and toxicity.

Reviews, discussions and seminars focused on the research of scientists who have made significant contributions to the science of toxicology.

Reports and discussions on journal and review articles and presentation of personal research results.

Reports and discussions.

Individualized for students desiring research experience in any of the areas of pharmacology.

Individualized course for students desiring research experience in any of the areas of toxicology.

Includes topics not presently covered in courses, which are pertinent to current departmental research and areas of recent development in the literature.

Basic principles of toxicology as emphasized by recent developments in the biochemical toxicology literature.

A study of managed care pharmacy within the United States health care system, with emphasis on managed care organization and control, pharmacy benefits design and management, outcomes measurement, pharmacoeconomics, health care provider and client education, benefits plan financing and marketing, and legal issues of managed care pharmacy.

A study of modern management techniques applicable in terminal drug distribution. Special emphasis is placed upon quantitative methods and the utilization of electronic data processing.

Current developments in Pharmacy Administration. A course for students needing exposure to topics not covered in other Department of Pharmacy Practice offerings.

Overview of physico-chemical, biopharmaceutic, and physiologic factors controlling the delivery of drug and their sites of action.

The science and technology of freeze drying, including fundamentals of heat and mass transfer gas systems, process design considerations, and formulation strategies with emphasis on stabilization of therapeutic proteins.

A study of the physico-chemical and mathematical treatment in pharmaceutical systems. Topics center on thermodynamics, activity coefficients, acids and bases, solubility, complexation solubilization and protein binding.

Emphasis is on the application of the laws of diffusion to dissolution, membrane transport and release of drugs from dosage forms.

A study of the kinetics and mechanisms of drug degradation in the solid and liquid states and drug stabilization.

A discussion of absorption, distribution, and clearance mechanisms, and their impact on concentration-time profiles and drug response.

Interfacial phenomena, colloid chemistry.

A study of the harmful effects of toxic chemicals on biological systems. Emphasis is on mechanisms of toxicant action and on practical applications of modern techniques to assess toxicity and hazard.

Demonstrates the detrimental effects on the immune system and/or inflammatory response, by a variety of physical and chemical xenobiotics. Emphasis is placed on the mechanisms of chemical and drug-induced immunosuppression, autoimmune response, and allergic response.