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4009. Structure and Function of Biological Macromolecules

3.00 credits

Prerequisites: MCB 2000 or 3010, which may be taken concurrently, or instructor consent.

Grading Basis: Graded

Fundamentals of protein structure and the forces that stabilize structure. Topics include recurrent structural motifs, molecular ancestry/homology, evolution of protein structure, structure-function correlations, and the structural basis of regulation. Discussion of the techniques used to investigate structure, including X-ray diffraction, NMR, TEM, AFM, structure prediction, and computational simulations. Advanced topics may include chaperones, structural genomics and the roles of misfolded proteins in disease.

Last Refreshed: 26-MAY-23 AM
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Term Campus Instruction Mode Instructor Section Session Schedule Location Enrollment Notes
Spring 2023 Storrs In Person Alexandrescu, Andrei 001 Reg TuTh 12:30pm‑1:45pm
TLS 263 16/16