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Prerequisites: BIOL 1107; CHEM 2241 or 2443; open to juniors or higher; open to ENVS and Allied Health Sciences majors, others with instructor consent. Concurrent enrollment in one of the following is strongly recommended: MCB 2000, 2410, 2413 or 2210, 3010.
Grading Basis: Graded
Basic principles in tumor biology will be presented including the biochemical basis of cell transformation, proliferation, and metastasis. Molecular mechanisms by which environmental chemicals interact with DNA and other cellular components will be discussed. The role of proto-oncogenes, tumor suppressor genes, and their products will be covered. Biological markers of cancer risk and exposure will be included.