University of Connecticut

Physiology and Neurobiology (PNB) 2015-2016

Head of Department: Professor Larry Renfro

Department Office: Room 67, Torrey Life Science Building

Major requirements

1401. Honors Core: Computational Molecular Biology

(Also offered as BME 1401, CSE 1401, and MCB 1401.) Three credits.

Introduction to research in computational biology through lectures, computer lab exercises, and mentored research projects. Topics include gene and genome structure, gene regulation, mechanisms of inheritance, biological databases, sequence alignment, motif finding, human genetics, forensic genetics, stem cell development, comparative genomics, early evolution, and modeling complex systems. CA 3.

2250. Animal Physiology

Three credits. Prerequisite: BIOL 1107 and either 1108 or 1110.

Physiological mechanisms and regulation in vertebrate animals.

2264-2265. Human Physiology and Anatomy

Four credits each semester. Three class periods and one 3-hour laboratory. Prerequisite: BIOL 1107, and one of CHEM 1122 or 1124Q or 1127Q. Not open to students who have passed PNB 22742275. These courses must be taken in sequence to obtain credit, and may not be counted toward the Biological Sciences or Physiology and Neurobiology majors.

Fundamentals of human anatomy and physiology for students in medical technology, physical therapy, nursing, and education (Sport Science). A fee of $20 is charged for each course.

2274-2275. Enhanced Human Physiology and Anatomy

Four credits each semester. Three class periods and one 3-hour laboratory. Prerequisite: BIOL 1107, and either CHEM 1124Q or 1127Q. Not open to students who have passed PNB 22642265. Must be taken in sequence to obtain credit.

Fundamentals of human physiology and anatomy enhanced through inquiry-based laboratories. A fee of $20 is charged for each course.

3120W. Scientific Writing in Physiology and Neurobiology

One credit. Prerequisite: One 2000-level course in PNB; ENGL 1010 or 1011 or 2011; open to juniors or higher. Instructor consent required.

Principles of effective scientific writing focusing on the communication of physiology and neurobiology to lay audiences.

3180. Field Study in Physiology and Neurobiology

Variable (1 to 4) credits. Hours by arrangement. Prerequisite: Open with consent of department head. May be repeated for a total of up to 6 credits. One credit may be earned for each 42 hours of pre-approved activities up to a maximum of 4 credits. May be applied towards the major with permission of department head subject to the PNB major’s 3-credit research group limitation. Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatisfactory).

Supervised field work at an off-campus research organization or business. Activities that meet objectives consistent with a major in Physiology and Neurobiology must be planned and agreed upon in advance by the job site supervisor, the faculty coordinator and the student.

3251. Biology of the Brain

Three credits. Two class periods. Prerequisite: One 2000-level course in PNB or instructor consent; open to juniors or higher.

Brain functions, from molecular and cellular to overall central nervous system organization. Topics of current scientific interest.

3252. Physiological Model Systems

Three credits. Prerequisite: PNB 2250, 22742275, or instructor consent; open to juniors or higher. Recommended preparation: undergraduate class in basic comparative animal physiology.

Advanced, in-depth examination of animal comparative physiology.

3260. Stem Cell Biology

Three credits. Prerequisite: PNB 2250 or 2274; or consent of instructor. Recommended preparation: MCB 2000 or 2210 or 2410 (which may be taken concurrently).

Principles of stem cell biology and the use and applications of stem cells in research and therapy. Emphasis on molecular, cellular and physiological properties of stem cells, mechanisms of differentiation, use of recombinant DNA technology and application of stem cells in disease models.

3262. Mammalian Endocrinology

Two credits. Two class periods. Prerequisite: One 2000-level course in PNB or instructor consent; open to juniors or higher.

Functions of hormones in mammalian physiology emphasizing humans.

3263WQ. Investigations in Neurobiology

Three credits. One 1-hour discussion, one 4-hour laboratory period. Prerequisite: PNB 2250 or PNB 22742275; ENGL 1010 or 1011 or 2011; open to juniors or higher.

Experimental investigations in neurobiology. Emphasis on designing and carrying out independent research projects, and on communicating the results. A fee of $20 is charged for this course.

3264W. Molecular Principles of Physiology

Four credits. Two class periods and one 4-hour laboratory. Prerequisite: PNB 2274, MCB 2410, or MCB 3010; ENGL 1010 or 1011 or 2011; open to juniors or higher; instructor consent required.

Case study of a disease: genetics and inheritance patterns, molecular defects, including transcription and post-transcription defects, physiological defects, therapeutic approaches.

3265. Comparative Endocrinology

Three credits. Prerequisite: A 2000-level course in PNB or instructor consent; open to juniors or higher.

The evolution of hormonal signaling systems in invertebrates and vertebrates.

3270. Molecular Endocrinology

(Also offered as MCB 3210.) Three credits. Prerequisite: BIOL 1107; open to juniors and seniors only. Recommended preparation: PNB 3262.

Molecular mechanism(s) of hormone action in vertebrates and invertebrates. Molecular and genetic characterization of hormones, receptors, and signal transduction, and hormone actions at the molecular, cellular, and organismal levels. Includes student presentations on selected papers.

3275. Biology of Synaptic Transmission

First nine weeks. Two credits. Prerequisite: One 2000-level course in PNB or instructor consent; open to juniors or higher. Not open to students who have taken PNB 3276. Recommended preparation: MCB 2000 or 3010.

Various neurotransmitter systems in the brain including anatomy, physiology, cell biology and biochemistry. Neurotransmitters, receptors and transporters at synapses. Synaptic signaling pathways and molecules.

3276. Molecular Neuroanatomy

Three credits. Prerequisite: One 2000-level course in PNB or instructor consent; open to juniors or higher. Recommended preparation: MCB 2000 or 3010.

Introduction to molecular neurobiology and the anatomy of the brain, and integration of the molecular systems with anatomical structure and function.

3278. Patient and the Healer

Two credits. Two class periods. Prerequisite: Consent of instructor required.

Introductory grounding and experience for students interested in the healing professions in how patients and families experience illness, and what it’s like to be a professional health provider.

3279. Insights into Dental Science and Clinical Medicine

One credit. Weekly 2-hour lecture for ten weeks. May be repeated for credit.

Presentations by Medical and Dental School faculty on basic sciences supporting dental and medical clinical practices. Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatisfactory).

3293. Foreign Study

Credits and hours by arrangement. Prerequisite: Open to juniors or higher; consent of Department Head or Key Advisor required, normally to be granted prior to the student’s departure. May count toward the major with consent of Department Head or Key Advisor. May be repeated for credit.

Special topics taken in a foreign study program.

3294. Undergraduate Seminar

Credits and hours by arrangement. Prerequisite: Open to juniors or higher. May be repeated for credit with a change in topic.

3295. Special Topics

Credits and hours by arrangement. Prerequisites and recommended preparation vary; open to juniors or higher. With a change in content, may be repeated for credit.

3298. Variable Topics

Three credits. Prerequisite: Open to juniors or higher. With a change in topic, may be repeated for credit. Prerequisites and recommended preparation vary.

3299. Independent Study

Credits and hours by arrangement. Prerequisite: Open only with consent of instructor and the department honors committee. May be repeated for credit with change in topic.

Designed for the advanced undergraduate student who desires to pursue a special problem as an introduction to independent investigation.

4162. Neuroethology

Three credits. Prerequisite: PNB 2274 or consent of instructor. Recommended preparation: PNB 3251.

Neural mechanisms of stereotyped behavior in vertebrates and invertebrates, emphasizing model systems. Shaping of these systems by environmental requirements and the evolutionary histories of the animals.

4296W. Senior Research Thesis in Physiology and Neurobiology

Three credits. Hours by arrangement. Prerequisite: Three credits of PNB 3299, which may be taken concurrently; ENGL 1010 or 1011 or 2011; open to juniors or higher; open only with consent of instructor and departmental honors committee. Not limited to honors students.

Special research or independent investigation for advanced undergraduates. Involves research and writing a thesis.

4400. Biology of Nervous System Diseases

Three credits. Prerequisite: Either PNB 2274 or 3251; one course from MCB 2000, 2210, 2400, 2410, or 3010; or instructor consent.

Basic principles of genetics, molecular and cell biology, and physiology as applied to the mechanisms of disease and repair processes in the nervous system. Topics include established concepts and areas of current research on chronic neurodegenerative, synaptic, and demyelinating disorders, acute trauma and cerebrovascular disorders, and plasticity and repair.

 

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